Successful Genome-Wide Scan in Paired Blood and Buccal Samples
نویسندگان
چکیده
منابع مشابه
Successful genome-wide scan in paired blood and buccal samples.
Interest in genome-wide association studies to identify susceptibility alleles for cancer is growing, and several are currently planned or under way. Although the feasibility of collecting buccal cell samples as an alternative to venous blood samples as a source of genomic DNA has been shown, the validity of using DNA from buccal cells for genome-wide scans has not been assessed. We used 46 pai...
متن کاملA genome-wide scan to detect signatures of recent selection in Australian Merino sheep
Domestication and selection are processes that conserve the pattern of genetic diversities between and within populations. Identification of genomic regions that are targets of selection for phenotypic traits is one of the main aims of research in animal genetics. An approach for identifying divergently selected regions of the genome is to compare FST values among loci to estimate the genetic v...
متن کاملFeasibility of High-Throughput Genome-Wide Genotyping using DNA from Stored Buccal Cell Samples
It is unclear if buccal cell samples contain sufficient human DNA with adequately sized fragments for high throughput genetic bioassays. Yet buccal cell sample collection is an attractive alternative to gathering blood samples for genetic epidemiologists engaged in large-scale genetic biomarker studies. We assessed the genotyping efficiency (GE) and genotyping concordance (GC) of buccal cell DN...
متن کاملGenome-Wide Identification of Somatic Aberrations from Paired Normal-Tumor Samples
Genomic copy number alteration and allelic imbalance are distinct features of cancer cells, and recent advances in the genotyping technology have greatly boosted the research in the cancer genome. However, the complicated nature of tumor usually hampers the dissection of the SNP arrays. In this study, we describe a bioinformatic tool, named GIANT, for genome-wide identification of somatic aberr...
متن کاملGenome-wide scan of exfoliation syndrome.
PURPOSE Exfoliation syndrome (XFS) is an age-related ocular condition that is characterized by the accumulation of fibrillogranular extracellular material in intra- and extraocular tissues. The purpose of the present study was to identify the genetic basis of XFS in a large Finnish family. METHODS A genome-wide scan with 1000 microsatellite markers was performed in an extended family from an ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2007
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-06-0859